Analytical Data
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基因名
GRIN3B
- Application
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别名
NR3B; N-methyl-D-aspartate receptor subtype 3B
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种属
Mouse
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q91ZU9
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表达区间
Ala102~Lys369
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分子量
55kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRIN3B, a member of the NMDA receptor family, is of great interest due to its significant role in synaptic transmission and plasticity in the central nervous system. Recent studies have implicated mutations in the GRIN3B gene in various neurological disorders, including intellectual disability and epilepsy, suggesting that understanding its functional properties could provide insights into these conditions. The GRIN3B receptor exhibits unique pharmacological profiles and regulatory mechanisms compared to other NMDA receptors, which may contribute to its diverse physiological functions. Additionally, recombinant GRIN3B protein has been utilized in experimental settings to elucidate its biophysical characteristics, ligand binding affinities, and interactions with other synaptic proteins. Research focused on GRIN3B reconstitution and functional assays has the potential to unravel the molecular mechanisms underlying its role in neuronal signaling and its alterations in disease states. Therefore, the recombinant production and detailed study of GRIN3B protein are essential for advancing our understanding of its contributions to neurobiology and developing potential therapeutic strategies targeting NMDA receptor-related pathologies.
