Analytical Data
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Gene name
ITPR1
- Application
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Alternative Names
IP3R; IP3R1; Insp3r1; SCA15; SCA16; Spinocerebellar Ataxia 15; IP3 receptor isoform 1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14643
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Expression Region
Gly112~Val287
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITPR1 (Inositol 1,4,5-trisphosphate receptor type 1) is a critical calcium release channel found in the endoplasmic reticulum, playing a vital role in cellular signaling processes. Research into ITPR1 has gained momentum due to its involvement in various physiological functions and its implications in pathological conditions, such as neurodegenerative diseases, cancer, and cardiac disorders. As a major mediator of intracellular calcium signaling, ITPR1 regulates numerous cellular activities, including muscle contraction, neurotransmitter release, and immune responses. Abnormalities in ITPR1 function can lead to calcium homeostasis imbalance, contributing to disease progression. Understanding the structural and functional aspects of ITPR1 can provide insights into its regulatory mechanisms and interaction with other cellular components. Recent advances in recombinant protein technology have facilitated the production of ITPR1 proteins, enabling researchers to study their biochemical properties, mechanisms of action, and potential therapeutic targets. Consequently, ITPR1 has emerged as a significant focus in biomedical research, aiming to develop strategies for modulation of its activity to treat associated disorders. The exploration of ITPR1 and its pathways offers new avenues for therapeutic interventions, highlighting its importance in both health and disease.
