Analytical Data
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Gene name
GNa11
- Application
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Alternative Names
GA11; Guanine Nucleotide-Binding Protein Subunit Alpha-11; Guanine nucleotide-binding protein G(y) subunit alpha
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29992
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Expression Region
Met1~Val359
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Molecular Weight
46kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNa11, or guanine nucleotide-binding protein subunit alpha-11, is a member of the G-protein family that plays a crucial role in various cellular signaling pathways. Research on GNa11 has gained traction due to its involvement in regulating physiological processes such as cell growth, differentiation, and various signal transduction mechanisms. Mutations in the GNA11 gene have been linked to several medical conditions, including tumors and other pathologies, underscoring its importance in both health and disease. The study of GNa11 recombinant proteins is pivotal for understanding the molecular mechanisms underlying G-protein signaling and its implications in pathology. Scientists aim to produce and purify GNa11 recombinant proteins to facilitate structural and functional studies, which can elucidate the protein's role in signal transmission and receptor interaction. Understanding GNa11's activity could potentially lead to the development of targeted therapies for diseases associated with its dysregulation. This research not only expands our knowledge of G-protein biology but also offers insights into therapeutic strategies for relevant diseases. The characterization of GNa11 recombinants will enable further exploration of its biochemical properties, interactions with other signaling proteins, and involvement in cellular responses, paving the way for future advancements in both basic and applied biomedical research.
