Analytical Data
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基因名
BRD1
- Application
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别名
BRL; BRPF2; BR140-like protein; Bromodomain and PHD finger-containing protein 2
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95696
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表达区间
Gln579~Asp1058
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分子量
83kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRD1 is a member of the bromodomain and extraterminal (BET) family of proteins, which play critical roles in various cellular processes, including transcription regulation, chromatin remodeling, and the recruitment of transcriptional coactivators. The study of BRD1 has gained significant attention due to its implications in several diseases, particularly in neurodevelopmental disorders and certain types of cancer. Research indicates that BRD1 is involved in modulating gene expression by interacting with acetylated lysines on histones and non-histone proteins, thereby influencing cellular signaling pathways and gene regulatory networks. Additionally, abnormalities in BRD1 expression levels or function have been associated with neuropsychiatric conditions such as schizophrenia. Consequently, understanding the structural and functional characteristics of BRD1, as well as its mechanisms of action, is pivotal for elucidating its role in health and disease. Recent advances in recombinant protein technology have facilitated the expression and purification of BRD1, enabling detailed investigations into its biochemical properties and interactions with other cellular factors. This research not only enhances our understanding of BRD1's biological functions but also opens potential avenues for therapeutic interventions aimed at modulating its activity in disease contexts. Thus, the study of BRD1 recombinant protein is critical for both basic research and the development of novel therapeutic strategies targeting bromodomain-containing proteins.
