Analytical Data
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Gene name
BRD2
- Application
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Alternative Names
FSRG1; NAT; RING3; RNF3; Really interesting new gene 3 protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25440
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Expression Region
Met1~Pro243
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRD2, a member of the bromodomain and extraterminal (BET) protein family, plays a crucial role in the regulation of gene expression through its interaction with acetylated lysines on histones and other proteins. Research on BRD2 has gained momentum due to its involvement in various biological processes, including inflammation, cell cycle regulation, and differentiation. Abnormal expression of BRD2 is linked to several diseases, such as cancer and neurodegenerative disorders, making it a potential therapeutic target. The study of BRD2 recombinant protein allows for a better understanding of its structure-function relationship and its role in cellular pathways. By expressing BRD2 in suitable host systems, researchers can investigate its binding properties, post-translational modifications, and interactions with other proteins. This foundational knowledge is essential for exploring BRD2 as a drug target and developing small molecules or inhibitors that could modulate its activity in disease contexts. Consequently, the research on BRD2 recombinant protein not only provides insights into fundamental biological mechanisms but also holds promise for novel therapeutic strategies in managing diseases associated with BRD2 dysregulation.
