Analytical Data
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Gene name
XPO5
- Application
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Alternative Names
RANBP21; Exp5; Ran-binding protein 21
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HAV4
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Expression Region
Ala2~Gln180
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Molecular Weight
25kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XPO5, or Exportin 5, is a significant nuclear transport receptor primarily involved in the export of pre-microRNAs and specific RNA molecules from the nucleus to the cytoplasm, playing a crucial role in gene regulation and post-transcriptional control. Recent studies have highlighted the importance of XPO5 in various biological processes, including cell proliferation, differentiation, and stress response, as well as its implications in diseases such as cancer and neurodegenerative disorders. Given the central role of microRNAs in regulating gene expression, understanding the mechanisms of XPO5 and its interactions is vital for developing targeted therapeutic strategies. The research into XPO5 recombinant proteins seeks to elucidate its structural and functional properties, enabling scientists to dissect its interactions with cargo RNAs and other proteins within the nuclear export pathway. Additionally, characterizing XPO5 through biochemical and biophysical approaches could reveal critical insights into the molecular mechanisms of RNA transport and its regulatory networks, potentially uncovering novel targets for intervention in diseases characterized by aberrant RNA processing and transport. As a result, XPO5 is emerging as a focal point in the study of RNA biology, emphasizing the need for in-depth investigations into its recombinant forms to advance our understanding of cellular RNA dynamics and their impact on health and disease.
