Analytical Data
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基因名
gABRa6
- Application
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别名
GABA(A) receptor subunit alpha-6
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16305
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表达区间
Gln20~Tyr242
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GABRA6 protein, a subunit of the GABA-type A receptor, plays a crucial role in inhibitory neurotransmission within the central nervous system. Its involvement in processes such as anxiety, epilepsy, and other neuropsychiatric disorders has garnered significant research interest. The GABA receptor, being a major player in mediating the inhibitory effects of gamma-aminobutyric acid (GABA), is instrumental in maintaining the balance between excitatory and inhibitory signals in the brain. The GABRA6 subunit, in particular, contributes to the receptor's pharmacological properties and its response to various modulators, including benzodiazepines and neurosteroids. Understanding the structural and functional dynamics of GABRA6 is essential for deciphering its role in normal physiology and its potential implications in disease states. The development of recombinant GABRA6 proteins allows for advanced biophysical and pharmacological studies, facilitating insights into receptor assembly, subunit interactions, and the impact of genetic variations on receptor function. This research holds promise for identifying novel therapeutic targets and improving interventions for conditions associated with dysregulated GABAergic signaling.
