Analytical Data
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Gene name
gABRb1
- Application
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Alternative Names
GABA(A) receptor subunit beta-1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P18505
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Expression Region
His26~Tyr245
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GABAB receptors, consisting of GABAB1 and GABAB2 subunits, are G protein-coupled receptors that play a crucial role in the central nervous system by mediating inhibitory neurotransmission. The GABAB1 subunit is essential for receptor formation and ligand binding, making it a significant target in neurological research. Studies have shown that GABAB receptors are involved in various physiological and pathological processes, including anxiety, depression, epilepsy, and addiction. The recombinant expression of GABAB1 protein in heterologous systems allows for detailed investigation of its structure, function, and pharmacological properties. Additionally, understanding the receptor's molecular mechanisms can aid in the development of novel therapeutic strategies for treating neurological disorders. Recent advances in cryo-electron microscopy and structural biology have facilitated the visualization of GABAB receptor complexes, providing insights into their activation and signaling pathways. As a result, research on GABAB1 recombinant protein is vital for advancing our knowledge of GABAergic signaling and its implications for brain function and dysfunction. This background underscores the importance of GABAB1 research in the context of neuropharmacology and therapeutic interventions.
