Analytical Data
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基因名
Synaptotagmin VI
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简介
The Ptk7 protein is a receptor involved in multiple cellular processes, including cell proliferation and migration. It plays a crucial role in regulating embryonic development and tissue homeostasis. Synaptotagmin VI Protein, Human (N-His) is the recombinant human-derived Synaptotagmin VI protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Synaptotagmin-6; Synaptotagmin VI; SytVI; SYT6
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
NP_995320
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表达区间
V275-L425
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蛋白长度
Partial
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Synaptotagmin VI (Syt VI) is a member of the synaptotagmin family of proteins, which are crucial for calcium-mediated neurotransmitter release in the nervous system. It contains multiple C2 domains that bind calcium ions, playing a significant role in synaptic vesicle trafficking and exocytosis. Research has shown that Syt VI is involved in regulating the release of various neurotransmitters, including GABA and glutamate, and particularly influences synaptic transmission in both central and peripheral nervous systems. The study of Syt VI is particularly important for understanding synaptic plasticity and neuronal communication, as alterations in its expression or function have been implicated in various neurodevelopmental disorders and neurodegenerative diseases. Recombinant Syt VI proteins are often utilized in biochemical and biophysical studies to elucidate their functional mechanisms, including their interactions with phospholipids and involvement in synaptic vesicle fusion. By expressing Syt VI in vitro, researchers can dissect the precise roles of its different domains under varying calcium concentrations and membrane environments, leading to insights into the molecular underpinnings of neurotransmission and potential therapeutic targets for synaptic dysfunctions.
