Analytical Data
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基因名
AP3b1
- Application
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别名
HPS; PE; HPS2; ADTB3; ADTB3A; Clathrin assembly protein complex 3 beta-1 large chain; Adaptor protein complex AP-3 subunit beta-1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00203
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表达区间
Met1~Leu233
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP3B1, a gene encoding the beta subunit of the adaptor protein complex 3 (AP-3), plays a critical role in mediating the sorting and trafficking of proteins within the endosomal/lysosomal pathways. Mutations in AP3B1 have been implicated in a rare genetic disorder known as Hermansky-Pudlak syndrome (HPS), which is characterized by oculocutaneous albinism, platelet disorders, and an increased risk of lung and bowel fibrosis. Research on AP3B1 recombinant protein has garnered significant attention due to its potential to elucidate the mechanisms of intracellular protein transport and its implications for understanding HPS pathology. By producing and purifying AP3B1, scientists can investigate its structural properties, binding interactions, and functional roles in cellular processes. Furthermore, recombinant AP3B1 can serve as a valuable tool for drug development, as insights gained from its study may lead to novel therapeutic strategies to manage symptoms or mitigate the effects of conditions associated with dysfunctional protein trafficking. Overall, exploring AP3B1 recombinant protein offers significant potential not only for advancing our understanding of the cellular mechanisms underlying various diseases but also for developing targeted interventions to improve patient outcomes.
