Analytical Data
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基因名
VPS13D
- Application
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种属
Mouse
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
B1ART2
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表达区间
Pro730~Gln1062
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分子量
69kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS13D is a member of the VPS13 family, which plays crucial roles in organelle contact sites and lipid transport, contributing to cellular homeostasis. Its significance has become increasingly apparent in the context of neurodegenerative diseases, particularly Parkinson's disease, where mutations in VPS13D have been linked to susceptibility. Research indicates that VPS13D is involved in the regulation of mitochondrial function and lipid metabolism, suggesting a protective role against cellular stress. Additionally, its interactions with various proteins within the endosomal-lysosomal pathway highlight its potential as a therapeutic target. Understanding the structure and function of VPS13D is critical for elucidating its role in cellular physiology and pathology, paving the way for novel approaches in the treatment of relevant disorders. The ongoing study of VPS13D reconstituted proteins aims to uncover the detailed mechanisms of its action, providing insights that could lead to innovative strategies for managing neurodegeneration and related conditions.
