Analytical Data
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基因名
ABCC10
- Application
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别名
MRP7; SIMRP7; Multidrug Resistance Associated Protein 7
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T3U5
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表达区间
Val1246~Pro1492
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC10, also known as ATP-binding cassette sub-family C member 10, is a member of the ATP-binding cassette (ABC) transporters, which are integral membrane proteins involved in the transport of various molecules across cellular membranes. Research on ABCC10 has garnered significant attention due to its role in drug resistance, particularly in cancer therapy. It has been identified as a potential mediator of the efflux of chemotherapeutic agents, thereby contributing to the reduced efficacy of cancer treatments. Several studies have linked ABCC10 expression levels to clinical outcomes in cancer patients, highlighting its importance in understanding resistance mechanisms. Additionally, ABCC10 is involved in the transport of various endogenous substrates, including certain lipids and xenobiotics, suggesting its broader physiological relevance. The investigation into the recombinant expression of ABCC10 protein allows for a deeper understanding of its structure-function relationships, transport mechanisms, and potential as a therapeutic target. Expanding the knowledge on ABCC10 could pave the way for novel strategies to overcome drug resistance in cancer therapy, enhancing the effectiveness of existing treatments and improving patient outcomes. Consequently, the study of ABCC10 is not only crucial for cancer research but also for developing innovative approaches to manage drug resistance in various diseases.
