Analytical Data
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基因名
HLA-A*02:01&B2M&HBV(FLLTRILTI) Tetramer
- Application
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别名
hepatitis B virus
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A140T913 (G25-T305)&P61769
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表达区间
A0A140T913 (G25-T305)&P61769 (I21-M119)&FLLTRILTI
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分子量
260-265 kDa under Non reducing (N)
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The HLA-A*02:01/B2M/HBV (FLLTRILTI) tetramer is a recombinant protein that has garnered significant attention in the field of immunology and virology, particularly regarding the human immune response to hepatitis B virus (HBV) infection. HLA-A*02:01 is a widely studied major histocompatibility complex (MHC) class I molecule that plays a crucial role in presenting viral peptides to CD8+ T cells, thereby initiating an immune response. The specific peptide FLLTRILTI, derived from the HBV core protein, is known to effectively elicit T cell responses in patients with chronic HBV infection. By creating a tetrameric complex with HLA-A*02:01 and β2-microglobulin (B2M), researchers can directly visualize and quantify HBV-specific CD8+ T cells in peripheral blood or liver tissues. This tool is invaluable for understanding the dynamics of T cell responses during HBV infection and for evaluating potential immunotherapeutic strategies. The study of this tetramer not only enhances our comprehension of the adaptive immune response against HBV but also provides insights into the mechanisms of viral persistence and clearance. As therapies targeting HBV continue to evolve, the HLA-A*02:01/B2M/HBV (FLLTRILTI) tetramer serves as a critical instrument for monitoring immune responses in vaccine trials and therapeutic interventions, with the ultimate goal of improving patient outcomes in chronic HBV infection.
