Analytical Data
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基因名
HARS1
- Application
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别名
Histidyl-tRNA synthetase
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种属
Human
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表达系统
Baculovirus
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12081
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表达区间
2-504aa
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分子量
58.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HARS1, or Human Histidyl-tRNA Synthetase 1, is a crucial enzyme involved in protein synthesis, specifically in the attachment of histidine to its corresponding tRNA, a process vital for the proper translation of genetic information into functional proteins. Research into HARS1 has gained attention due to its emerging roles beyond housekeeping functions in protein synthesis, particularly in cellular signaling and potential involvement in various diseases. Aberrant expression of HARS1 has been linked to conditions such as cancer and autoimmune diseases, highlighting its significance in pathological contexts. Additionally, the enzyme's interactions with other biomolecules suggest it may play a role in regulating cell growth and differentiation. Recombinant HARS1 protein studies are essential for elucidating the enzyme's biochemical properties and understanding its physiological and pathological roles. Through techniques such as gene cloning, expression in suitable host cells, and purification, researchers aim to obtain functional HARS1 protein for structural and kinetic analysis. Overall, this research not only enhances our understanding of fundamental cellular processes but also opens avenues for potential therapeutic strategies targeting diseases associated with HARS1 dysregulation.
