Analytical Data
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基因名
SP-17
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简介
SP-17 protein acts as a sperm surface zona pellucida binding protein, facilitating high-affinity spermatozoa binding to the zona pellucida.It potentially engages in binding interactions with zona pellucida and carbohydrates.Existing as a homodimer, SP-17 may interact with ROPN1, suggesting a cooperative role in sperm-egg interactions and fertilization processes.SP-17 Protein, Mouse (His) is the recombinant mouse-derived SP-17 protein, expressed by E.coli , with N-His labeled tag.
- Application
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别名
Sperm surface protein Sp17; CT22; Sp17-1; Sperm protein 17; SPA17;
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种属
Mouse
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表达系统
E. coli
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标签
N-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q62252
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表达区间
M1-N149
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蛋白长度
Full Length
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分子量
20-25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The SP-17 recombinant protein has garnered significant interest in scientific research, particularly in the fields of immunology and reproductive biology. SP-17 is identified as a proliferation-related spermatozoa antigen and is predominantly expressed in the sperm of various species including humans. Its role as a potential target for immunocontraception has spurred investigations into its ability to elicit an immune response. Researchers aim to explore its implications in infertility treatments, vaccine development, and contraceptive strategies. Understanding the molecular structure and function of SP-17 can provide insights into its interactions with the immune system, potentially leading to innovative approaches in reproductive health. The development of SP-17 as a recombinant protein facilitates its purification and characterization, allowing for detailed studies on its immunogenic properties and the mechanisms by which it may evoke antibody production. Moreover, the ongoing exploration of SP-17’s role in sperm motility and fertilization processes highlights its biological significance, suggesting that it could also serve as a biomarker for male fertility assessments. This multifaceted approach to studying SP-17 reinforces its potential applications in both clinical settings and the advancement of reproductive technologies, making it a focal point for further biomedical research.
