Analytical Data
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Gene name
TSHR
- Application
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Alternative Names
LGR3; HTSHR-I; Thyrotropin Receptor; TSH Receptor
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P21463
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Expression Region
Pro28~Gly245
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Molecular Weight
28kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The Thyroid-Stimulating Hormone Receptor (TSHR) is a critical G protein-coupled receptor that plays a vital role in regulating thyroid function by mediating the effects of thyroid-stimulating hormone (TSH). Abnormalities in TSHR signaling can lead to various thyroid disorders, including hyperthyroidism and autoimmune diseases such as Graves' disease. Understanding the structure and function of TSHR is essential for developing targeted therapies for these conditions. Recent advances in recombinant protein technology have enabled researchers to produce functional TSHR proteins for detailed study. Recombinant TSHR proteins allow for the analysis of receptor-ligand interactions, signaling pathways, and the identification of potential pharmacological agents. Additionally, these studies facilitate the investigation of TSHR mutations associated with thyroid diseases, paving the way for personalized medicine approaches. As research continues to uncover the complexities of TSHR biology, the potential for novel therapeutic strategies to manage thyroid-related disorders becomes increasingly promising.
