Analytical Data
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Gene name
DOK5
- Application
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Alternative Names
Downstream of tyrosine kinase 5Insulin receptor substrate 6 ;IRS-6 ;IRS6
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P104
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Expression Region
1-198aa
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Molecular Weight
38.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of DOK5 (Downstream of Kinase 5) recombinant protein has gained considerable attention in recent years due to its critical role in cellular signaling pathways. DOK5 is part of the DOK family, which is characterized by the presence of a Phosphotyrosine Binding (PTB) domain that enables interactions with various receptor tyrosine kinases. Research indicates that DOK5 acts as a scaffold protein, facilitating the assembly of signaling complexes that regulate crucial cellular processes such as proliferation, differentiation, and survival. Dysregulation of these pathways has been implicated in several diseases, including cancers and metabolic disorders. By producing recombinant DOK5 protein, scientists aim to elucidate its molecular interactions and functional roles in signaling pathways, with the potential to identify novel therapeutic targets. This research is particularly significant given the increasing understanding of the importance of protein-protein interactions in signal transduction and the complexity of cellular responses. Furthermore, recombinant DOK5 can be utilized in various applications, including structure-function studies, drug discovery, and as a biomarker in disease states. Overall, the exploration of DOK5 recombinant protein not only enhances our understanding of fundamental biological processes but also opens avenues for therapeutic advancements in related pathologies.
