Analytical Data
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Gene name
H2BC3
- Application
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Alternative Names
Histone H2B.1Histone H2B.f ;H2B/f
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33778
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Expression Region
2-126aa
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Molecular Weight
29.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H2BC3, a member of the histone H2B family, plays a pivotal role in the regulation of gene expression through its incorporation into chromatin. Research on H2BC3 has gained momentum due to its potential implications in various biological processes, including cell proliferation, differentiation, and apoptosis. Notably, aberrant expression of H2BC3 has been implicated in different types of cancers, making it a significant focus in cancer biology. Understanding the structural and functional characteristics of the H2BC3 protein offers insights into its interactions with DNA and other chromatin-associated proteins, illuminating its role in epigenetic regulation. Recent studies have highlighted the importance of post-translational modifications of H2BC3, which may further influence its functional dynamics and interaction networks within the nucleus. As interest grows in the development of therapeutic strategies targeting chromatin dynamics, H2BC3 stands out as a promising candidate due to its potential as both a biomarker and a therapeutic target in oncological research. The ongoing exploration of H2BC3’s structure-function relationships and its regulatory mechanisms is expected to contribute significantly to our understanding of epigenetic control in health and disease.
