Analytical Data
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Gene name
HMGN4
- Application
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Alternative Names
HMGN4; HMG17L3; NHC; High mobility group nucleosome-binding domain-containing protein 4; Non-histone chromosomal protein HMG-17-like 3; Non-histone chromosomal protein
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00479
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Expression Region
1-90aa
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Molecular Weight
36.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HMGN4, a member of the high mobility group nucleosomal binding protein family, plays a crucial role in chromatin structure and function. Due to its ability to bind to nucleosomes, HMGN4 is implicated in regulating gene expression, DNA repair, and cellular responses to stress. Its unique properties, including the modulation of histone modifications and the alteration of chromatin dynamics, make it a target of interest in various areas of biological research. Recent studies have suggested that HMGN4 may be involved in cancer progression and metastasis, underscoring the need for a deeper understanding of its biological roles. Researchers aim to produce recombinant HMGN4 protein to investigate its biochemical properties and interactions in vitro. By elucidating the mechanisms by which HMGN4 influences chromatin architecture and gene regulatory networks, the research potentially opens new avenues for therapeutic interventions in diseases associated with chromatin dysregulation. Overall, the recombinant HMGN4 protein serves as a valuable tool for dissecting molecular pathways in cellular physiology and disease.
