Analytical Data
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Gene name
Ikzf2
- Application
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Alternative Names
Ikaros family zinc finger protein 2 (Helios) (Zfpn1a2) (Znfn1a2)
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Species
Mouse
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P81183
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Expression Region
1-526aa
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Molecular Weight
66.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IKZF2, also known as Helios, is a member of the Ikaros family of zinc finger transcription factors, which play crucial roles in the development and function of various immune cells, particularly T cells and regulatory T cells (Tregs). Aberrant expression or mutations of IKZF2 have been implicated in several hematological malignancies, making it a significant focus of cancer research. The interest in IKZF2 recombination protein stems from its regulatory functions, which dictate the fate of immune cells and maintain immune homeostasis. Investigating the structural and functional properties of IKZF2 through recombinant protein studies allows researchers to unravel its mechanisms of action and its interactions with other proteins and DNA elements. This research can provide insights into therapeutic strategies for cancer and autoimmune diseases by potentially targeting IKZF2 pathways to restore normal immune function or inhibit tumor growth. Furthermore, IKZF2's role in Treg differentiation and stability highlights its potential as a biomarker for immunological disorders and a target for immunotherapy. Understanding IKZF2 at the molecular level is, therefore, essential for developing innovative interventions and improving patient outcomes in related diseases.
