Analytical Data
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基因名
KRT7
- Application
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别名
Cytokeratin-7 Short name: CK-7 Keratin-7 Short name: K7 Sarcolectin Type-II keratin Kb7
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08729
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表达区间
2-469aa
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分子量
67.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT7, or Keratin 7, is a type of intermediate filament protein that plays a crucial role in the structural integrity and function of epithelial tissues. It is primarily expressed in simple epithelia, including glandular tissues and the respiratory tract. Research into KRT7 has gained significance due to its involvement in various physiological processes and pathological conditions, particularly its association with epithelial differentiation and proliferation. Elevated KRT7 expression is frequently observed in certain cancers, such as lung and breast cancer, where it may serve as a biomarker for tumor progression and metastasis. The study of recombinant KRT7 proteins allows for a deeper investigation into their functional roles and interactions within cellular environments. By producing KRT7 in recombinant systems, researchers can analyze its structural properties, investigate its regulatory mechanisms, and understand its contribution to disease states. Moreover, recombinant KRT7 can serve as a valuable tool in drug development and therapeutic strategies, particularly for targeting cancers that exhibit aberrant expression of keratins. Overall, the research surrounding KRT7 recombinant proteins is essential for elucidating the intricate roles of keratin in both normal physiology and disease pathology, paving the way for potential clinical applications and innovative treatments.
