Analytical Data
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Gene name
KRT7
- Application
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Alternative Names
Cytokeratin-7 Short name: CK-7 Keratin-7 Short name: K7 Sarcolectin Type-II keratin Kb7
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08729
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Expression Region
2-469aa
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Molecular Weight
67.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT7, or Keratin 7, is a type of intermediate filament protein that plays a crucial role in the structural integrity and function of epithelial tissues. It is primarily expressed in simple epithelia, including glandular tissues and the respiratory tract. Research into KRT7 has gained significance due to its involvement in various physiological processes and pathological conditions, particularly its association with epithelial differentiation and proliferation. Elevated KRT7 expression is frequently observed in certain cancers, such as lung and breast cancer, where it may serve as a biomarker for tumor progression and metastasis. The study of recombinant KRT7 proteins allows for a deeper investigation into their functional roles and interactions within cellular environments. By producing KRT7 in recombinant systems, researchers can analyze its structural properties, investigate its regulatory mechanisms, and understand its contribution to disease states. Moreover, recombinant KRT7 can serve as a valuable tool in drug development and therapeutic strategies, particularly for targeting cancers that exhibit aberrant expression of keratins. Overall, the research surrounding KRT7 recombinant proteins is essential for elucidating the intricate roles of keratin in both normal physiology and disease pathology, paving the way for potential clinical applications and innovative treatments.
