Analytical Data
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Gene name
KSR1
- Application
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Alternative Names
KSR
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IVT5
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Expression Region
404-598aa
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Molecular Weight
25.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KSR1, or Kinase Suppressor of Ras 1, is a crucial protein that plays a significant role in the Ras-Raf-MEK-ERK signaling pathway, which is essential for various cellular processes, including growth, differentiation, and survival. The dysregulation of this signaling pathway is often implicated in the development of various cancers and other diseases. Research into KSR1 has gained momentum due to its potential as a therapeutic target; understanding its structure and function can provide insights into how it contributes to Ras-mediated signaling. KSR1 acts as a scaffold protein, facilitating the interaction between different kinases within this pathway. Studies have demonstrated that KSR1 is not merely a passive participant but actively regulates the signaling cascades by influencing the localization and activity of its binding partners. Furthermore, emerging evidence suggests that KSR1 may also have roles beyond Ras signaling, impacting other cellular processes. The characterization of KSR1, particularly through the study of its recombinant protein form, has been pivotal for elucidating its function in signal transduction. Investigations into KSR1 structure-function relationships, binding interactions, and regulatory mechanisms have the potential to uncover novel strategies for cancer treatment. As researchers assess KSR1's role in both normal physiology and pathophysiology, the focus on its recombinant protein offers valuable opportunities for drug discovery and the development of targeted therapies aimed at modulating KSR1 activity or disrupting its interactions within signaling complexes.
