Analytical Data
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Gene name
GPRC5D
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简介
GPRC5D，G 蛋白偶联受体，是一种 C 型 7 次跨膜受体蛋白。GPRC5D 是一种在恶性浆细胞上表达的孤儿受体，在正常组织中表达有限。GPRC5D 是治疗复发性或难治性 (R/R) 多发性骨髓瘤 (MM) 的有希望的靶点。 GPRC5D Protein-Nanodisc, Human (HEK293, His, Flag) is the recombinant human-derived GPRC5D protein, expressed by HEK293, with C-His and N-Flag labeled tag.
- Application
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Alternative Names
GPRC5D; G protein-coupled receptor, family C, group 5, member D; G-protein coupled receptor family C group 5 member D; orphan G-protein coupled receptor; MGC129713; MGC129714;
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Species
Human
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Source
HEK293
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Tag
C-His;N-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZD1-2
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Expression Region
Y2-C300
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPRC5D, a member of the G protein-coupled receptor family, has garnered significant attention in recent years for its potential role in various pathological conditions, particularly in cancer biology. Unlike other G protein-coupled receptors, GPRC5D is predominantly expressed in certain hematologic malignancies, such as multiple myeloma, making it a promising target for therapeutic intervention. Research has shown that GPRC5D is involved in key signaling pathways that influence cell proliferation, survival, and apoptosis, highlighting its importance in tumor progression. The development of GPRC5D recombinant proteins facilitates the exploration of this receptor's structure and function, paving the way for the identification of specific inhibitors or antibodies that can modulate its activity. Additionally, understanding the dynamics of GPRC5D through recombinant protein studies provides insights into its potential as a biomarker for disease prognosis and therapeutic response. As scientists continue to investigate the molecular mechanisms underpinning GPRC5D's role in cancer, the therapeutic strategies leveraging GPRC5D are evolving, hinting at new avenues for targeted treatments in hematologic disorders. These advances underscore the importance of GPRC5D in the landscape of cancer research and therapeutic development, positioning it as a crucial focus for future studies aimed at improving patient outcomes.
