Analytical Data
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Gene name
MRPS6
- Application
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Alternative Names
MRPS6; C21orf101; RPMS628S ribosomal protein S6; mitochondrial; MRP-S6; S6mt; Mitochondrial small ribosomal subunit protein bS6m
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P82932
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Expression Region
1-125aa
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Molecular Weight
41.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPS6, a member of the mitochondrial ribosomal protein family, plays a pivotal role in mitochondrial translation and is crucial for the proper assembly of mitochondrial ribosomes. Research on MRPS6 has gained attention due to its involvement in various cellular processes and its potential implications in mitochondrial dysfunction, which is often linked to a range of diseases, including neurodegenerative disorders and certain types of cancer. The protein is integral in the synthesis of mitochondrial-encoded proteins that are essential for oxidative phosphorylation, the process by which cells generate ATP. Consequently, mutations or aberrations in MRPS6 can lead to compromised mitochondrial function, highlighting its importance in cellular metabolism. Further studies are needed to elucidate the specific mechanisms by which MRPS6 influences mitochondrial activity and its role in disease pathology, making it a crucial target for research aimed at understanding mitochondrial biology and developing therapeutic strategies for mitochondrial-related disorders. This research could pave the way for potential interventions that restore mitochondrial function or target the specific pathways affected by MRPS6 alterations, ultimately contributing to improved therapeutic outcomes in associated diseases.
