Analytical Data
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Gene name
PTHLH
- Application
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Alternative Names
Parathyroid hormone-like protein ;PLP
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P12272
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Expression Region
37-175aa
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Molecular Weight
19.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTHLH (Parathyroid Hormone-Like Hormone) is a critical peptide involved in various physiological processes, particularly in bone development, calcium homeostasis, and cellular proliferation. Originally discovered for its role in regulating chondrocyte function and bone mineralization, PTHLH has gained attention due to its implications in endocrine signaling, cancer biology, and tissue regeneration. The recombinant protein forms of PTHLH facilitate in-depth studies of its biological functions and therapeutic potential. This research has revealed that PTHLH is not only essential for skeletal development but also plays a significant role in the metastatic processes of certain cancers, such as breast and lung cancer, where it can influence tumor growth and progression. Furthermore, the ability of PTHLH to modulate signaling pathways involved in osteoblast and osteoclast differentiation positions it as a promising target for developing treatments for osteoporosis and other bone-related disorders. Consequently, the production and characterization of recombinant PTHLH proteins are crucial for advancing our understanding of its multifaceted roles and exploring potential clinical applications in regenerative medicine and oncology. Understanding the molecular mechanisms of PTHLH signaling may lead to innovative therapeutic strategies, making PTHLH recombinant proteins a focal point in biomedical research.
