Analytical Data
-
Gene name
PTH2R
- Application
-
Alternative Names
Parathyroid hormone 2 receptor; Parathyroid hormone receptor precursor ; PTH 2 receptor ; PTH2 receptor; Pth2r; PTH2R_HUMAN; Pthr 2; Pthr2
-
Species
Human
-
Source
E. coli
-
Tag
N- His-SUMO
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P49190
-
Expression Region
27-145aa
-
Molecular Weight
29.6 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The parathyroid hormone 2 receptor (PTH2R) is a G protein-coupled receptor (GPCR) that, along with its ligand, parathyroid hormone 2 (PTH2), plays a significant role in various physiological processes, including renal function, neuronal signaling, and the regulation of bone metabolism. Research into PTH2R has gained momentum due to its potential implications in various diseases, including osteoporosis, chronic kidney disease, and neurodegenerative disorders. Unlike its more widely studied counterpart, PTH1R, which primarily mediates calcium homeostasis, PTH2R’s distinct signaling pathways suggest unique biological roles that are not yet fully understood. Previous studies have indicated that PTH2R may influence the release of neuropeptides and modulate the immune response, highlighting its potential as a therapeutic target. However, the lack of structural and functional data has hindered advancements in drug development. The generation of recombinant PTH2R protein is essential for elucidating its structure-function relationship and for studying the receptor's signaling mechanisms in detail. This recombinant protein can facilitate binding assays, receptor activation studies, and screening for small molecules or peptides that could serve as modulators of PTH2R activity. Understanding the precise role of PTH2R in health and disease may pave the way for novel therapeutic interventions aimed at managing conditions linked to this receptor. Thus, PTH2R remains a promising subject of research with the potential to enhance our knowledge of GPCR biology and contribute to drug discovery efforts targeting related diseases.
