Analytical Data
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Gene name
PSME1
- Application
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Alternative Names
11S regulator complex subunit alpha
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q06323
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Expression Region
1-249aa
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Molecular Weight
55.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSME1, or Proteasome Activator Subunit 1, is a crucial component of the 26S proteasome, which plays a vital role in protein degradation and cellular regulation. This protein is involved in the activation of the proteasome's catalytic core, facilitating the degradation of ubiquitinated proteins that are essential for various cellular processes such as cell cycle regulation, apoptosis, and immune response. Aberrations in proteasomal function, including those related to PSME1, have been implicated in numerous diseases, including cancer and neurodegenerative disorders. Research on recombinant PSME1 protein, therefore, focuses on understanding its structural and functional properties, the mechanisms of proteasomal activation, and its potential as a therapeutic target. By studying PSME1, scientists aim to unravel the complexities of proteasomal pathways and develop novel strategies for manipulating these processes in disease contexts. Additionally, recombinant PSME1 protein can serve as a valuable tool in biochemical assays to explore proteasome dynamics, providing insights into how proteasomal activity can be modulated, which may lead to the development of drugs that enhance or inhibit proteasome function in various diseases. Understanding the role of PSME1 in the proteasome's activity is crucial for advancing our knowledge of protein homeostasis and its implications in health and disease.
