Analytical Data
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Gene name
PSMB8
- Application
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Alternative Names
Low molecular mass protein 7 Macropain subunit C13 Multicatalytic endopeptidase complex subunit C13 Proteasome component C13 Proteasome subunit beta-5i Really interesting new gene 10 protein
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28062
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Expression Region
73-276aa
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Molecular Weight
42.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMB8, a member of the proteasome subunit beta type family, plays a critical role in the proteolytic processing of ubiquitinated proteins, thus contributing to the regulation of various cellular processes, including the removal of damaged proteins and the presentation of antigens to the immune system. Research into PSMB8 has gained traction due to its association with several diseases, particularly in the context of immune disorders and cancer. In particular, mutations or dysregulation of PSMB8 have been linked to specific forms of autoimmune diseases such as SLE (Systemic Lupus Erythematosus) and certain malignancies, thereby underscoring its importance in maintaining cellular homeostasis and immune function. Advances in recombinant protein technology have facilitated the production and study of PSMB8, allowing researchers to elucidate its structure-function relationships and explore its potential as a therapeutic target. Understanding the mechanistic pathways involving PSMB8 not only aids in delineating its role in health and disease but also opens avenues for the development of innovative treatment strategies aimed at modulating its activity or compensating for its dysfunction in various pathological conditions. The ongoing exploration of PSMB8’s functions and interactions continues to provide valuable insights into the complexities of intracellular protein degradation and its implications for human health.
