Analytical Data
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Gene name
PSIP1
- Application
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Alternative Names
CLL-associated antigen KW-7Dense fine speckles 70KDA protein ;DFS 70Lens epithelium-derived growth factorTranscriptional coactivator p75/p52
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75475
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Expression Region
1-530aa
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Molecular Weight
76.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PSIP1 protein, also known as Positive Transcription Elongation Factor b (P-TEFb) subunit 2, plays a crucial role in the regulation of gene expression by promoting transcriptional elongation. Research into PSIP1 has gained significant attention due to its involvement in various cellular processes, including RNA polymerase II activity, chromatin remodeling, and responses to cellular stress. Notably, PSIP1 has been linked to several diseases, particularly cancer and neurodegenerative disorders, making it a potential target for therapeutic interventions. Its ability to interact with other cellular factors and influence pathways that control cell proliferation and survival underscores its importance in both normal physiology and disease states. Recent studies using recombinant PSIP1 protein have provided insights into its structural properties and functional mechanisms, facilitating a deeper understanding of its role in transcriptional regulation. These investigations pave the way for developing novel strategies to modulate PSIP1 activity, which could have significant implications for treating diseases associated with transcriptional dysregulation.
