Analytical Data
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基因名
ADORA1
- Application
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别名
/
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30542
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表达区间
1-326aa
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分子量
39.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADORA1, or Adenosine A1 receptor, is a G protein-coupled receptor that plays a critical role in various physiological processes, including cardiac function, neurotransmission, and immune response. Research on ADORA1 has gained momentum due to its involvement in key pathological conditions such as heart failure, neurological disorders, and cancer. The receptor’s activation triggers a cascade of intracellular signaling, influencing numerous downstream effectors that regulate cellular activities. The recombinant expression of ADORA1 protein is pivotal for elucidating its structure-function relationship and for drug discovery efforts aimed at targeting the receptor for therapeutic purposes. Advances in biotechnology have enabled the production of high-quality recombinant ADORA1, making it possible to conduct detailed pharmacological studies and structural analyses. This research is not only essential for understanding the receptor's biological significance but also for developing selective modulators that could lead to new treatment strategies for diseases associated with ADORA1 dysregulation. The ongoing studies focus on optimizing the expression systems and purification processes, improving the yield and functionality of the recombinant protein, and utilizing techniques like X-ray crystallography and cryo-electron microscopy to uncover the intricate mechanisms of ADORA1 signaling. Overall, the study of ADORA1 recombinant protein is integral to expanding our knowledge of this receptor's role in health and disease, paving the way for innovative therapeutic approaches.
