Analytical Data
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基因名
RYR3
- Application
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别名
Brain ryanodine receptor-calcium release channelBrain-type ryanodine receptorType 3 ryanodine receptor
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15413
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表达区间
3934-4181aa
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分子量
32.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RYR3, or Ryanodine Receptor 3, is a key calcium release channel located in the sarcoplasmic reticulum of various cells, notably in the central nervous system and cardiac tissues. It plays a critical role in calcium signaling, which is essential for many physiological processes, including muscle contractions and neurotransmitter release. Dysregulation of RYR3 has been implicated in several pathologies, such as cardiac diseases, neurodegenerative disorders, and various calcium-related syndromes. The recombinant production of RYR3 protein is pivotal for understanding its structure-function relationship and for developing potential therapeutic strategies. Research efforts focus on characterizing the protein's functional properties, regulation mechanisms, and interactions with other cellular components. Advances in recombinant technology have enabled the expression and purification of RYR3 at a significant scale, allowing for biophysical and biochemical studies. Understanding RYR3's role in pathophysiological contexts could lead to novel insights into disease mechanisms and the identification of drug targets, paving the way for innovative treatments. Hence, the study of RYR3 recombination is not only crucial for basic biology but also for the development of interventions for calcium dysregulation-related diseases.
