Analytical Data
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Gene name
SEC16A
- Application
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Alternative Names
SEC16 homolog A
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15027
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Expression Region
1943-2154aa
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Molecular Weight
26.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SEC16A is a critical protein involved in the regulation of secretory pathways within eukaryotic cells, particularly concerning the formation of transport vesicles at the endoplasmic reticulum (ER). It serves as a scaffold for several key components necessary for cargo export from the ER, thus playing an essential role in maintaining cellular homeostasis and protein quality control. Dysregulation or mutations in SEC16A have been linked to various diseases, including developmental disorders and certain types of cancer, highlighting its significance in cellular biology. Research has focused on elucidating the molecular mechanisms by which SEC16A facilitates the organization of the ER and its interactions with other proteins in the secretory pathway. Additionally, studies have explored its potential as a therapeutic target, aiming to manipulate SEC16A function to restore normal secretory activity in affected cells. Understanding the intricate role of SEC16A in health and disease could pave the way for novel therapeutic approaches in treating conditions arising from secretory pathway dysfunction.
