Analytical Data
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基因名
SEC16A
- Application
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别名
SEC16 homolog A
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15027
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表达区间
1943-2154aa
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分子量
26.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEC16A is a critical protein involved in the regulation of secretory pathways within eukaryotic cells, particularly concerning the formation of transport vesicles at the endoplasmic reticulum (ER). It serves as a scaffold for several key components necessary for cargo export from the ER, thus playing an essential role in maintaining cellular homeostasis and protein quality control. Dysregulation or mutations in SEC16A have been linked to various diseases, including developmental disorders and certain types of cancer, highlighting its significance in cellular biology. Research has focused on elucidating the molecular mechanisms by which SEC16A facilitates the organization of the ER and its interactions with other proteins in the secretory pathway. Additionally, studies have explored its potential as a therapeutic target, aiming to manipulate SEC16A function to restore normal secretory activity in affected cells. Understanding the intricate role of SEC16A in health and disease could pave the way for novel therapeutic approaches in treating conditions arising from secretory pathway dysfunction.
