Analytical Data
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基因名
SRP19
- Application
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别名
Signal recognition particle 19 kDa protein; signal recognition particle 19kDa; SRP19; SRP19_HUMAN
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09132
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表达区间
2-144aa
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SRP19, a crucial component of the signal recognition particle (SRP) pathway, plays a significant role in the targeting and translocation of nascent polypeptides to the endoplasmic reticulum (ER) in eukaryotic cells. The SRP complex, comprising RNA and proteins, ensures the proper localization of secretory and membrane proteins, which is vital for cellular function and homeostasis. Recent studies have highlighted the importance of SRP19 in regulating the assembly and stability of the SRP complex, impacting the efficiency of protein translation and membrane integration. Given its pivotal function, SRP19 has become a focal point for understanding the molecular mechanisms underlying protein trafficking and its implications in diseases associated with protein misfolding and transport dysfunction. Furthermore, the exploration of SRP19 as a potential therapeutic target opens new avenues in drug development for conditions stemming from cellular transport anomalies. As a recombinant protein, SRP19 can be utilized in structural and functional studies to elucidate its interaction with other SRP components and to investigate its role in various cellular contexts, thereby providing deeper insights into the SRP pathway and its regulation.
