Analytical Data
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Gene name
CATSPER1
- Application
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Alternative Names
(CatSper1)(hCatSper)
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Species
Human
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Source
Yeast
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NEC5
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Expression Region
1-445aa
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Molecular Weight
52.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CATSPER1 (Cation Channel Sperm Associated 1) is a gene encoding a protein that plays a crucial role in male fertility, specifically in the function of sperm. It is part of the CATSPER (Cation Channel of Sperm) protein family, which is essential for the generation of the hyperactivated motility of sperm, a key feature for successful fertilization. Research has indicated that mutations or disruptions in the CATSPER1 gene can lead to impaired sperm function and consequently male infertility. Understanding the structure and function of CATSPER1 is critical for elucidating the mechanisms behind sperm motility and fertility. Recent studies have focused on the recombinant expression of the CATSPER1 protein to investigate its properties and interactions with other proteins within the sperm cell. These studies aim to provide insights into the ion channel activity of CATSPER1, its regulation, and its relevance in sperm physiology. Moreover, exploring the potential of CATSPER1 as a biomarker for male infertility could lead to improved diagnostic methods and therapeutic strategies. Overall, the investigation of CATSPER1 recombinant protein is significant for advancing our understanding of reproductive biology and addressing male reproductive health issues.
