Analytical Data
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Gene name
AIFM1
- Application
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Alternative Names
AIFM1；AIF；PDCD8；Apoptosis-inducing factor 1. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95831
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Expression Region
121-613aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMEEVPQDKAPSHVPFLLIGGGTAAFAAARS IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGK ERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGS QITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISRE VKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLS NWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVG LEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGR RRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVD SSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSTPA VPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHE DLNEVAKLFNIHED
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AIFM1, or Apoptosis Inducing Factor Mitochondria-associated 1, is a pivotal protein involved in regulating apoptosis and mitochondrial function. Research into AIFM1 has gained significant momentum due to its essential roles in cellular processes and its implications in various diseases, particularly in neurodegenerative disorders and cancers. Mutations in the AIFM1 gene have been associated with X-linked intellectual disability and syndromic conditions, highlighting its importance in neural development and function. The characterization of AIFM1 recombinant protein has become crucial for elucidating its structural and functional properties, which could provide insights into its mechanism of action in programmed cell death and mitochondrial dynamics. Moreover, understanding AIFM1's interactions with other cellular components can pave the way for therapeutic strategies aimed at modulating its activity in disease contexts. As the exploration of AIFM1 continues, the development of recombinant protein studies not only enhances our comprehension of its biological significance but also fosters potential avenues for clinical applications in treating conditions linked to AIFM1 dysfunction.
