Analytical Data
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Gene name
ARHGDIb
- Application
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Alternative Names
ARHGDIb；GDIA2；GDID4；RAP1GN1；Rho GDP-dissociation inhibitor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P52566
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Expression Region
1-201aa
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AA Sequence
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHMTE KAPEPHVEED DDDELDSKLN YKPPPQKSLK ELQEMDKDDE SLIKYKKTLL GDGPVVTDPK APNVVVTRLT LVCESAPGPI TMDLTGDLEA LKKETIVLKE GSEYRVKIHF KVNRDIVSGL KYVQHTYRTG VKVDKATFMV GSYGPRPEEY EFLTPVEEAP KGMLARGTYH NKSFFTDDDK QDHLSWEWNL SIKKEWTE
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Molecular Weight
49 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGDIb (Rho GDP-dissociation inhibitor beta) is a member of the Rho GDI family, which plays a critical role in regulating Rho GTPases, a group of proteins involved in various cellular processes such as cytoskeletal dynamics, cell migration, and signal transduction. Research indicates that ARHGDIb functions primarily by sequestering Rho GTPases in their inactive GDP-bound state, thereby preventing their action in cellular signaling pathways. Dysregulation of ARHGDIb has been implicated in several pathological conditions, including cancer, where altered Rho GTPase signaling can promote tumorigenesis, metastasis, and altered cell adhesion. Consequently, understanding the structure and function of ARHGDIb is crucial for elucidating its role in both normal physiology and disease. Additionally, the production of recombinant ARHGDIb has garnered interest for its potential therapeutic applications and for providing insights into Rho GTPase regulation. By studying the recombinant form of ARHGDIb, researchers aim to develop inhibitors or modulators that could influence Rho GTPase activity, thus opening new avenues for treatment strategies in diseases characterized by aberrant Rho signaling. Further investigations into the biochemical properties, interaction partners, and downstream effects of ARHGDIb are essential in advancing our knowledge of its functional mechanisms and contributions to cellular regulation.
