Analytical Data
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Gene name
CDH1
- Application
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Alternative Names
CDH1；CDH1；FYR；FZR；Fizzy-related Protein homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P12830
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Expression Region
155-709aa
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AA Sequence
DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPA
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Molecular Weight
61.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDH1, or cadherin-1, is a crucial cell adhesion molecule primarily expressed in epithelial tissues, playing a significant role in maintaining tissue integrity and regulating cellular interactions. Its impairment is associated with various malignancies, particularly hereditary diffuse gastric cancer (HDGC), linked to germline mutations in the CDH1 gene. Furthermore, CDH1 is involved in the E-cadherin-mediated signaling pathways that control cell proliferation, differentiation, and apoptosis. Research on CDH1 recombinant proteins aims to elucidate their structure-function relationships, facilitating a deeper understanding of how mutations contribute to cancer progression. By producing recombinant CDH1, scientists can investigate its binding affinities and characterize the impact of specific mutations on its adhesive properties. This knowledge is crucial for developing targeted therapies and diagnostic tools for CDH1-related cancers. The study of CDH1 also extends to regenerative medicine and tissue engineering, where promoting proper cell adhesion is essential for successful graft integration and wound healing. Overall, the exploration of CDH1 recombinant proteins remains a vital area of research with promising implications for cancer biology, genetic counseling, and therapeutic strategies.
