Analytical Data
-
Gene name
MAP1A
- Application
-
Alternative Names
MAP1A；MAP1L；Microtubule-associated Protein 1A
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P78559
-
Expression Region
2567-2803aa
-
AA Sequence
DPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGRRAPGKAKPASPARRLDLRGKRSPTPGKGPADRASRAPPRPRSTTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALSSKGSSGAPVYVDLAYIPNHCSGKTADLDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIEF
-
Molecular Weight
30.0 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAP1A, or Microtubule-Associated Protein 1A, is a crucial protein involved in the regulation of microtubule dynamics and cellular structure. It plays a significant role in neuronal development, supporting the stability of microtubules and facilitating intracellular transport. Recent studies have highlighted MAP1A's involvement in neurodegenerative diseases, including Alzheimer's and tauopathies, where abnormal tau protein aggregation disrupts microtubule function. Understanding MAP1A's structure and dynamics through recombinant protein studies is essential for elucidating its role in neuronal health and disease. Researchers focus on developing recombinant forms of MAP1A to analyze its interactions with microtubules and other cellular proteins. This approach allows for a detailed examination of its binding properties, conformational changes, and the impact of post-translational modifications. Consequently, studying MAP1A recombinant proteins can illuminate potential therapeutic targets for neurodegenerative disorders, offering insight into how modulation of this protein could help restore normal microtubule function and improve neuronal resilience. The ongoing investigation into MAP1A's mechanisms highlights its importance in cell biology, particularly in understanding the complex interactions that govern neuronal stability and function.
