Analytical Data
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基因名
DUSP5
- Application
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别名
DUSP5；VH3；Dual specificity Protein phosphatase 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16690
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表达区间
1-384aa
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氨基酸序列
MKVTSLDGRQ LRKMLRKEAA ARCVVLDCRP YLAFAASNVR GSLNVNLNSV VLRRARGGAV SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR EESAARVVLT SLLACLPAGP RVYFLKGGYE TFYSEYPECC VDVKPISQEK IESERALISQ CGKPVVNVSY RPAYDQGGPV EILPFLYLGS AYHASKCEFL ANLHITALLN VSRRTSEACA THLHYKWIPV EDSHTADISS HFQEAIDFID CVREKGGKVL VHCEAGISRS PTICMAYLMK TKQFRLKEAF DYIKQRRSMV SPNFGFMGQL LQYESEILPS TPNPQPPSCQ GEAAGSSLIG HLQTLSPDMQ GAYCTFPASV LAPVPTHSTV SELSRSPVAT ATSC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUSP5, or dual specificity protein phosphatase 5, is a crucial member of the MAPK (mitogen-activated protein kinase) phosphatase family, playing a significant role in regulating cellular signaling pathways, particularly those involved in cell proliferation, differentiation, and apoptosis. Its function in dephosphorylating both tyrosine and serine/threonine residues makes DUSP5 an essential modulator of various intracellular signaling cascades, including the ERK (extracellular signal-regulated kinase) pathway. Dysregulation of DUSP5 has been implicated in several diseases, including cancer, where it can affect tumor growth and response to therapies. Given its pivotal role in these processes, DUSP5 has attracted attention as a potential therapeutic target. Research involving recombinant DUSP5 protein aims to elucidate its biochemical properties, interaction mechanisms, and functional implications in various cellular contexts. By producing and characterizing recombinant DUSP5, scientists seek to better understand its role in MAPK signaling and its potential as a biomarker or therapeutic target in diseases characterized by aberrant signaling pathways. Additionally, studying the recombinant form of DUSP5 can facilitate the development of novel inhibitors or modulators that could have clinical applications in cancer treatment and other disorders associated with MAPK signaling dysregulation. Overall, the investigation of DUSP5 through recombinant protein studies is critical for advancing our understanding of its biological functions and therapeutic potential.
