Analytical Data
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基因名
CD38
- Application
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别名
CD38；ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28907
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表达区间
46-300aa
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氨基酸序列
WRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
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分子量
56.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD38 is a glycoprotein that functions as an important regulatory enzyme in various physiological processes, including immune response, cell signaling, and calcium mobilization. Its expression is primarily found in immune cells, such as lymphocytes and macrophages, and it plays a critical role in cell activation and differentiation. CD38 is known to catalyze the conversion of NAD+ (nicotinamide adenine dinucleotide) into cyclic ADP-ribose and ADP-ribose, which are pivotal in calcium signaling pathways within cells. This makes CD38 a potential therapeutic target in various diseases, including hematological malignancies and autoimmune disorders. Research into recombinant CD38 proteins aims to explore their structural and functional properties, enhancing our understanding of how CD38 mediates its biological effects. Furthermore, the development of CD38-targeted therapies, such as monoclonal antibodies, has gained momentum, particularly in the context of multiple myeloma, where agents like daratumumab have shown promise. Overall, the study of CD38 recombinant proteins is crucial for elucidating its role in health and disease, offering insights that could lead to novel therapeutic strategies.
