Analytical Data
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Gene name
CD38
- Application
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Alternative Names
CD38；ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28907
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Expression Region
46-300aa
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AA Sequence
WRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
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Molecular Weight
56.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD38 is a glycoprotein that functions as an important regulatory enzyme in various physiological processes, including immune response, cell signaling, and calcium mobilization. Its expression is primarily found in immune cells, such as lymphocytes and macrophages, and it plays a critical role in cell activation and differentiation. CD38 is known to catalyze the conversion of NAD+ (nicotinamide adenine dinucleotide) into cyclic ADP-ribose and ADP-ribose, which are pivotal in calcium signaling pathways within cells. This makes CD38 a potential therapeutic target in various diseases, including hematological malignancies and autoimmune disorders. Research into recombinant CD38 proteins aims to explore their structural and functional properties, enhancing our understanding of how CD38 mediates its biological effects. Furthermore, the development of CD38-targeted therapies, such as monoclonal antibodies, has gained momentum, particularly in the context of multiple myeloma, where agents like daratumumab have shown promise. Overall, the study of CD38 recombinant proteins is crucial for elucidating its role in health and disease, offering insights that could lead to novel therapeutic strategies.
