Analytical Data
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Gene name
CDK16
- Application
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Alternative Names
CDK16；PCTAIRE1；PCTK1；Cyclin-dependent kinase 16
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q00536
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Expression Region
158-496aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSGFGKLET YIKLDKLGEG TYATVYKGKS KLTDNLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDIIHTEK SLTLVFEYLD KDLKQYLDDC GNIINMHNVK LFLFQLLRGL AYCHRQKVLH RDLKPQNLLI NERGELKLAD FGLARAKSIP TKTYSNEVVT LWYRPPDILL GSTDYSTQID MWGVGCIFYE MATGRPLFPG STVEEQLHFI FRILGTPTEE TWPGILSNEE FKTYNYPKYR AEALLSHAPR LDSDGADLLT KLLQFEGRNR ISAEDAMKHP FFLSLGERIH KLPDTTSIFA LKEIQLQKEA SLRSSSMPDS GRPAFRVVDT EF
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK16, also known as cyclin-dependent kinase 16, is a member of the cyclin-dependent kinase family and plays a crucial role in regulating various cellular processes, including cell cycle progression, transcription, and neuronal signaling. Its activity is tightly regulated by cyclins and other cofactors, which allows it to respond to cellular signals and environmental cues. Recent studies have highlighted the importance of CDK16 in cancer biology, particularly its involvement in the proliferation and survival of cancer cells, suggesting its potential as a therapeutic target. Moreover, CDK16 has been implicated in neurodegenerative diseases, where its dysregulation may contribute to neuronal dysfunction and cell death. The recombinant expression of CDK16 provides a valuable tool for studying its biochemical properties, interaction with other proteins, and role in cellular pathways. Understanding the functional mechanisms of CDK16 through recombinant protein studies can pave the way for the development of targeted therapies that aim to modulate its activity for therapeutic benefit in cancer and neurodegenerative conditions. The generation of CDK16 recombinants not only facilitates the exploration of its structure-function relationship but also aids in screening potential inhibitors that could selectively disrupt its activity in pathological conditions. Hence, research into recombinant CDK16 serves as a foundation for advancing our understanding of its biological significance and therapeutic potential.
