Analytical Data
-
Gene name
CDK5RAP3
- Application
-
Alternative Names
CDK5RAP3;IC53;LZAP;CDK5 regulatory subunit-associated Protein 3
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q96JB5
-
Expression Region
1-506aa
-
AA Sequence
MGSSHHHHHH SSGLVPRGSH MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN LMGTSL
-
Molecular Weight
59 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDK5RAP3 (Cyclin-dependent kinase 5 regulatory subunit-associated protein 3) is a multifunctional protein that plays a crucial role in various cellular processes, including neuronal development, cell cycle regulation, and apoptosis. This protein acts as a regulatory subunit for the cyclin-dependent kinase 5 (CDK5) complex, which is essential for neuronal differentiation and synaptic function. Dysregulation of CDK5RAP3 has been implicated in several neurodegenerative diseases, such as Alzheimer's disease and schizophrenia, making it a significant focus of research in neurobiology and pathology. Furthermore, CDK5RAP3 has been shown to impact cancer biology, particularly through its interactions with signaling pathways that control cell proliferation and survival. Given its diverse functional roles and involvement in critical disease mechanisms, understanding the structure and function of recombinant CDK5RAP3 is vital for developing therapeutic strategies aimed at modulating its activity. Recombinant protein studies allow for the detailed investigation of its interactions and effects in cellular systems, providing insights into how CDK5RAP3 functions in both physiological and pathological contexts.











