Analytical Data
-
基因名
PHF6
- Application
-
别名
(PHD-like zinc finger protein)
-
种属
Human
-
表达系统
E. coli
-
标签
N- His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8IWS0
-
表达区间
2-312aa
-
分子量
39.2 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PHF6 (PHD Finger Protein 6) is a protein that has garnered attention in the field of molecular biology and cancer research due to its role as a potential tumor suppressor. The protein contains a PHD (plant homeodomain) finger, which is a type of zinc-finger domain that is known to be involved in the regulation of gene expression through chromatin modification. Mutations in the PHF6 gene have been associated with various hematological malignancies, including T-cell acute lymphoblastic leukemia, suggesting that PHF6 plays a critical role in normal hematopoiesis and cellular differentiation. Research has shown that PHF6 regulates the expression of genes involved in cell cycle progression and apoptosis, further illustrating its importance in maintaining cellular homeostasis. The study of recombinant PHF6 protein aims to elucidate its functional mechanisms, interaction partners, and the impact of its mutations on cellular pathways. Understanding these aspects could lead to insights into the development of targeted therapies for cancers associated with PHF6 dysregulation, thereby highlighting the importance of this protein in clinical research. Efforts to produce and characterize recombinant PHF6 proteins are essential for advancing our knowledge of its biological functions and therapeutic potential.
