Analytical Data
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基因名
SLC5A5
- Application
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别名
(Na(+)(-)(Natrium iodide transporter)(Sodium-iodide symporter)(Na(+)(-)(Solute carrier family 5 member 5)
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种属
Human
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表达系统
E. coli
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标签
C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92911
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表达区间
547-643aa
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分子量
17.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC5A5, also known as the sodium-iodide symporter (NIS), is a crucial membrane protein primarily expressed in the thyroid gland, where it plays a vital role in iodine uptake for thyroid hormone synthesis. The study of SLC5A5 is significant due to its implications in various medical conditions, including thyroid disorders, iodide deficiency, and certain types of cancer. Remarkably, the expression of SLC5A5 in non-thyroid tissues has sparked interest in its potential role in targeted therapies, especially in the context of radioactive iodine treatment for thyroid cancer. Moreover, the recombinant expression of SLC5A5 allows researchers to investigate its structure, function, and regulation in detail, providing insights into its transport mechanism and interactions with other molecules. Understanding the features of SLC5A5 at a molecular level is essential for developing novel therapeutic strategies and improving treatment options for patients with thyroid-related diseases. Additionally, as SLC5A5 is responsible for the uptake of iodine, a critical element for hormone production, the exploration of its recombinant protein offers opportunities for enhancing iodine delivery systems and addressing global iodine deficiency issues.
