Analytical Data
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Gene name
SLC5A5
- Application
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Alternative Names
(Na(+)(-)(Natrium iodide transporter)(Sodium-iodide symporter)(Na(+)(-)(Solute carrier family 5 member 5)
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Species
Human
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92911
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Expression Region
547-643aa
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Molecular Weight
17.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC5A5, also known as the sodium-iodide symporter (NIS), is a crucial membrane protein primarily expressed in the thyroid gland, where it plays a vital role in iodine uptake for thyroid hormone synthesis. The study of SLC5A5 is significant due to its implications in various medical conditions, including thyroid disorders, iodide deficiency, and certain types of cancer. Remarkably, the expression of SLC5A5 in non-thyroid tissues has sparked interest in its potential role in targeted therapies, especially in the context of radioactive iodine treatment for thyroid cancer. Moreover, the recombinant expression of SLC5A5 allows researchers to investigate its structure, function, and regulation in detail, providing insights into its transport mechanism and interactions with other molecules. Understanding the features of SLC5A5 at a molecular level is essential for developing novel therapeutic strategies and improving treatment options for patients with thyroid-related diseases. Additionally, as SLC5A5 is responsible for the uptake of iodine, a critical element for hormone production, the exploration of its recombinant protein offers opportunities for enhancing iodine delivery systems and addressing global iodine deficiency issues.
