Analytical Data
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Gene name
DNAJB4
- Application
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Alternative Names
DNAJB4；DNAJW；HLJ1;DnaJ homolog subfamily B member 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UDY4
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Expression Region
1-337aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGKDYYC ILGIEKGASD EDIKKAYRKQ ALKFHPDKNK SPQAEEKFKE VAEAYEVLSD PKKREIYDQF GEEGLKGGAG GTDGQGGTFR YTFHGDPHAT FAAFFGGSNP FEIFFGRRMG GGRDSEEMEI DGDPFSAFGF SMNGYPRDRN SVGPSRLKQD PPVIHELRVS LEEIYSGCTK RMKISRKRLN ADGRSYRSED KILTIEIKKG WKEGTKITFP REGDETPNSI PADIVFIIKD KDHPKFKRDG SNIIYTAKIS LREALCGCSI NVPTLDGRNI PMSVNDIVKP GMRRRIIGYG LPFPKNPDQR GDLLIEFEVS FPDTISSSSK EVLRKHLPAS
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DNAJB4 (DnaJ homolog subfamily B member 4) is a member of the DnaJ family of heat shock proteins, which play critical roles in protein folding, assembly, and transport, as well as in stress responses. Recent research has highlighted the significance of DNAJB4 in various cellular processes, including its involvement in the regulation of protein homeostasis and its potential role in diseases such as cancer and neurodegenerative disorders. The interest in DNAJB4 as a recombinant protein stems from its ability to interact with unfolded or misfolded proteins, thereby assisting in their proper refolding or degradation. Studies have shown that overexpression of DNAJB4 can enhance the survival of cells under stress conditions, making it a potential target for therapeutic interventions. Moreover, its unique structural features and functional properties make it an attractive subject for biochemical and structural analysis. As a result, scientists are increasingly focusing on the production and characterization of recombinant DNAJB4 to better understand its mechanism of action and to explore its therapeutic potential in diseases where protein misfolding is a contributing factor. Understanding DNAJB4's role at the molecular level could pave the way for new strategies in treating disorders linked to protein misfolding and aggregation, highlighting the importance of continued research in this area.
