Analytical Data
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基因名
SGLT1
- Application
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别名
SGLT1；NAGT；SGLT1；Sodium/glucose cotransporter 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13866
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表达区间
1-664aa
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氨基酸序列
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
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分子量
73.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of SGLT1 (Sodium-Glucose Cotransporter 1) recombinant protein has garnered significant interest due to its vital role in glucose absorption in the intestines and reabsorption in the kidneys. SGLT1 is a membrane protein that facilitates the transport of glucose into cells against its concentration gradient by coupling it with sodium ion transport. This mechanism is crucial for maintaining glucose homeostasis and energy balance in the body. Dysregulation of SGLT1 function has been linked to various metabolic disorders, including diabetes and malabsorption syndromes. Research on recombinant SGLT1 protein provides valuable insights into its structural and functional properties, enabling the development of targeted therapeutic strategies that could enhance glucose uptake in patients with glucose transport deficiencies. Furthermore, studying SGLT1 can also inform drug design, particularly in the context of SGLT inhibitors, which are used as anti-diabetic medications to reduce glucose reabsorption and lower blood sugar levels. Advances in recombinant DNA technology have facilitated the production of SGLT1 in heterologous systems, allowing for detailed biochemical and pharmacological studies. This research is crucial not only for understanding SGLT1’s physiological roles but also for developing novel treatments for conditions associated with its dysfunction.
