Analytical Data
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Gene name
DPP4
- Application
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Alternative Names
DPP4；ADCP2；CD26;Dipeptidyl peptidase 4
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Species
Human
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Source
293F cell
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Tag
Fc tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P27487
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Expression Region
29-766aa
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AA Sequence
NKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAE YGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYD LNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGK EDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDE SLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDH YLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTG WVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIG IEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVS FSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKL DFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLA STENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNK RIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDF QAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
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Molecular Weight
112.0kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Dipeptidyl peptidase-4 (DPP4) is a serine protease that plays a crucial role in glucose metabolism and immune regulation. Initially identified as an enzyme that inactivates incretin hormones, such as GLP-1 and GIP, which are vital for insulin secretion and glucose homeostasis, DPP4 has gained attention in various fields of research. Elevated DPP4 activity has been implicated in metabolic disorders, including type 2 diabetes and obesity, making it a potential therapeutic target. Additionally, DPP4 is expressed on various immune cells, suggesting its involvement in immune responses and inflammation. Recent studies have indicated that DPP4 might also play a role in cancer biology, as its activity can influence tumor cell proliferation and migration. The development of DPP4 inhibitors has proven beneficial in managing type 2 diabetes, leading to the exploration of DPP4 as a biomarker for disease progression and prognosis. Furthermore, investigations into DPP4 as a recombinant protein have potential applications in understanding its enzymatic mechanisms, its interactions with other proteins, and the development of novel therapeutic strategies. Overall, research on DPP4 and its recombinant forms presents exciting opportunities to deepen our understanding of its multifaceted roles in human health and disease.
