Analytical Data
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Gene name
EXOSC4
- Application
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Alternative Names
EXOSC4；RRP41；SKI6;Exosome complex component RRP41
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPD3
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Expression Region
1-245aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAGLELL SDQGYRVDGR RAGELRKIQA RMGVFAQADG SAYIEQGNTK ALAVVYGPHE IRGSRARALP DRALVNCQYS SATFSTGERK RRPHGDRKSC EMGLQLRQTF EAAILTQLHP RSQIDIYVQV LQADGGTYAA CVNAATLAVL DAGIPMRDFV CACSAGFVDG TALADLSHVE EAAGGPQLAL ALLPASGQIA LLEMDARLHE DHLERVLEAA AQAARDVHTL LDRVVRQHVR EASILLGD
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Molecular Weight
29 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EXOSC4, also known as Exosome Complex Component 4, is a vital component of the exosome complex, which plays a crucial role in RNA metabolism, including degradation, processing, and maturation of various RNA species. The exosome complex is essential for maintaining cellular RNA homeostasis, and its dysfunction is associated with various diseases, including cancers and genetic disorders. Recent studies have highlighted the significance of EXOSC4 in regulating gene expression and cellular responses under stress conditions. Researchers are increasingly interested in understanding the structural and functional properties of EXOSC4, particularly its interactions with other exosome components and its role in RNA substrate recognition. The study of recombinant EXOSC4 protein is pivotal for elucidating its mechanism of action, enabling the development of potential therapeutic strategies targeting RNA metabolism-related diseases. By investigating the biochemical properties and interactions of EXOSC4, researchers aim to uncover its contributions to RNA regulatory networks and its implications in the pathogenesis of various disorders. The recombinant protein serves as a valuable tool for functional assays, structural studies, and high-throughput screening, helping to unravel the complexities of exosomal RNA processing pathways. This research not only advances our fundamental understanding of RNA biology but also opens avenues for innovative therapeutic approaches leveraging the modulation of exosomal activities in human health and disease.
