Analytical Data
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基因名
EXOSC1
- Application
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别名
EXOSC1；CSL4;Exosome complex component CSL4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y3B2
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表达区间
1-195aa
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氨基酸序列
MAPPVRYCIP GERLCNLEEG SPGSGTYTRH GYIFSSLAGC LMKSSENGAL PVVSVVRETE SQLLPDVGAI VTCKVSSINS RFAKVHILYV GSMPLKNSFR GTIRKEDVRA TEKDKVEIYK SFRPGDIVLA KVISLGDAQS NYLLTTAENE LGVVVAHSES GIQMVPISWC EMQCPKTHTK EFRKVARVQP EFLQT
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC1, a crucial component of the exosome complex, plays a significant role in the degradation and processing of RNA molecules within eukaryotic cells. This multisubunit complex is essential for maintaining RNA homeostasis, regulating gene expression, and controlling mRNA stability. Dysregulation or mutations in EXOSC1 have been implicated in various diseases, including certain neurodegenerative disorders. The study of EXOSC1 recombinant protein is vital for understanding its precise molecular function, interactions with other RNA-binding proteins, and its role in RNA metabolism. By producing and characterizing EXOSC1 as a recombinant protein, researchers can delve into its biochemical properties, explore structure-function relationships, and develop potential therapeutic strategies to mitigate the effects of its dysfunction. Moreover, insights gained from these studies may also aid in elucidating the broader mechanisms of RNA regulation, ultimately contributing to our understanding of cell biology and the development of disease-modifying therapies.
