Analytical Data
-
基因名
LOXL2
- Application
-
别名
LOXL2；Lysyl oxidase homolog 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9Y4K0
-
表达区间
26-774aa
-
氨基酸序列
QYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRLAGQKRKHSEGRVEVY YDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDN LHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQ IENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAK NSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSC KLGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPL VRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEA VTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCN TPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMV VCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDG EDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAM EENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDC HRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECAN FGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDY SNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
-
分子量
85 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Lysyl oxidase like 2 (LOXL2) is a member of the lysyl oxidase family, which plays a crucial role in the extracellular matrix (ECM) remodeling and tissue homeostasis. It is known to catalyze the oxidative deamination of lysine residues, facilitating collagen and elastin cross-linking, which is vital for maintaining the structural integrity of tissues. Recent studies have highlighted the involvement of LOXL2 in various pathological conditions, including fibrosis, cancer metastasis, and cardiovascular diseases, making it a potential therapeutic target. The increased expression of LOXL2 has been associated with poor prognosis in several cancers, suggesting its role in tumor progression and the invasive behavior of cancer cells. Consequently, the development of LOXL2 recombinant proteins has garnered significant interest in the research community. These proteins can be utilized for understanding the precise biochemical mechanisms underlying LOXL2's role in ECM modulation and identifying novel inhibitors that may offer new therapeutic avenues. Moreover, the use of LOXL2 recombinant proteins can aid in the exploration of its interactions with other cellular components, providing insights into its contributions to cellular signaling pathways. By elucidating the molecular functions of LOXL2, researchers aim to establish a foundation for innovative treatments that target aberrant LOXL2 activity in disease contexts, thus advancing the field of translational medicine.
